Endocrine Abstracts

Background: Celiac disease is frequently associated with type 1 diabetes mellitus, but is usually ill-defined and not usually suspected until the disease become advance.Aim: To study the prevalence, clinical profile and glycemic variability and the effect of gluten free diet on growth and diabetic control in celiac type 1 diabetes patients in a tertiary care referral centre in north India.Materials and method: Total of 256 patients...

Background: Diabetic ketoacidosis is characterized by biochemical tired of hyperglycemia, acidosis, and ketonemia. It remains a life threatening condition despite improvement in diabetic care, timely identification and intervention remains the backbone of treatment.Aim and objectives: i) To evaluate the clinical and biochemical prognostic markers in diabetic ketoacidosis. ii) To correlate the various prognostic markers with mortality in diabetic ketoacid...

Background: Juvenile hypothyroidism is very common problem in developing parts of world, and produces various skeletal manifestations. One of them is short stature and it is the most common reason for referral to endocrinologist.Aim and objectives: To study the prevalence of short stature in juvenile hypothyroidism, to study the various radiological manifestations of juvenile hypothyroidism and to study the impact of treatment on growth velocity and vari...

We present the case of a 73-year-old woman, who presented with ascites and a history of left radical hemithyroidectomy for localized follicular thyroid carcinoma (FTC) 28 years ago. Computed tomography (CT) scanning of her body revealed extensive metastatic lesions. An omental biopsy showed features suggestive of thyroid follicular epithelial cancer. Serum thyroglobulin was raised at 127 μg/l. She died before the biopsy result was received. Two years before presentation, ...

Introduction: The prevalence of clinical obesity in women with polycystic ovarian syndrome (PCOS) is 50%. Weight loss is effective at enhancing insulin sensitivity, reducing hyperandrogenaemia, improving hirsutism and restoring menstrual regularity and fertility in PCOS. However, women with PCOS appear to be less responsive to weight loss interventions including some bariatric surgical procedures. The aim of this study was to compare weight loss outcomes of gastric bypass surg...

Obesity increases the risk of pregnancy-related complications such as miscarriage, foetal abnormalities, hypertension, diabetes, thrombosis, caesarean section and infection. Although bariatric surgery addresses some of these risks, women should defer pregnancy for 12-24 months postoperatively until weight loss has plateaued due to concerns regarding limited maternal weight loss and foetal nutritional deficiency. The aim of this study was to evaluate the impact of pregnancy on ...

Background: GH therapy in adolescents with childhood onset GH deficiency (CO-GHD) is often necessary to prevent adult GHD syndrome. This requires re-evaluation of the GH axis on attainment of final height.Aim: Retrospective review of outcome in young adults diagnosed with CO-GHD Design: Clinical details were collected on young adults with CO-GHD patients between 2005 and 2011 at one tertiary centre. Result: 62 former CO-GHD patients, 40 male: 22 female, ...

Methods: We retrospectively reviewed the medical notes of 39 patients who received radioiodine treatment (RAI) for thyrotoxicosis from 2004 until February 2010. Only 5.1% of patients had history of partial thyroidectomy; patients with previous history of RAI for thyrotoxicosis were excluded. All patients received written information leaflet for RAI.Results: Thirty (76.9%) patients were females and the median age of diagnosis was 59.5 years. 97.4% were Ca...

Methods: We retrospectively reviewed the medical notes of 39 patients who received radioiodine treatment (RAI) for thyrotoxicosis from 2004 until February 2010.Results: Thirty (76.9%) patients were females and the median age of diagnosis was 59.5 years. 17.9% had positive family history of thyrotoxicosis; current smokers (31%), ex-smokers (18%); Graves’ disease (56.4%), Multinodular goitre (41%), and unspecified diagnosis (2.6%). 18% of patients had...

Background: Hyperadrogenemia is one of the most commonly encountered endocrine disorders in reproductive-aged women. By far the most common causes of androgen excess are functional which account for more than 90% of cases. Androgen and ovarian tumours producing excess androgen are however very rare and only account for about 0.2% of cases.Case history: A 62-year-old lady admitted to hospital with pneumonia was found to have an ill defined, firm, non-tend...